Research
We develop innovative chemical tools at the intersection of synthetic chemistry, chemical biology, and drug discovery. By integrating molecular design, selective chemical transformations, and biological investigation, we seek new ways to understand and modulate biological systems and advance targeted therapeutics.
Synthetic Chemistry
We develop efficient and selective synthetic methodologies for constructing structurally complex and biologically relevant molecules. Integrating catalysis, photochemistry, and molecular design, our work expands the chemical tools available for biological research and drug discovery.
Asymmetric Catalysis
Development of stereoselective catalytic methodologies, including asymmetric cascade reactions, for the efficient construction of chiral molecules and pharmaceutically relevant scaffolds.
Photocatalysis
Investigation of light-driven catalytic transformations to achieve selective bond formation and molecular functionalization through controlled photochemical processes.
Medicinal Chemistry
Design and synthesis of bioactive small molecules and drug-like scaffolds, integrating medicinal chemistry principles and structure–activity relationship studies to guide molecular optimization.
Chemical Biology
We develop chemical tools to visualize, investigate, and regulate biomolecules in complex biological systems. Our research combines selective bioorthogonal reactivity, proximity-enabled methods, and biomolecular functionalization to investigate protein function and cellular processes.
Bioorthogonal Chemistry
Development of selective chemical reactions for molecular labeling, imaging, and controlled activation in living systems, enabling the investigation and manipulation of biological processes.
Proximity Chemistry
Development of proximity-enabled chemical strategies for the selective modification and functional regulation of proteins, with applications in understanding protein interactions and cellular signaling.
Biomolecular Engineering
Development of chemical approaches for the functionalization of peptides, proteins, and glycoconjugates, including bioconjugation technologies for antibody–drug conjugates and other biomolecular therapeutics.
Drug Discovery
We integrate medicinal chemistry, chemical biology, and computational approaches to develop new therapeutic strategies. Our research focuses on targeted protein modulation, selective drug activation, and AI-assisted molecular design for precision medicine.
Targeted Protein Degradation
Development of targeted protein degradation strategies, including PROTACs, molecular glues, and conjugate-based degraders, to selectively eliminate disease-associated proteins.
Precision Therapeutics
Design of selectively activated therapeutic agents, including bioorthogonal prodrugs and senolytic compounds, for applications in cancer, neurodegenerative diseases, and age-related disorders.
AI-Assisted Drug Discovery
Integration of artificial intelligence, molecular modeling, and experimental evaluation to support rational drug design, molecular optimization, and the discovery of new therapeutic candidates.